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Methotrexate Tablets IP 2.5 mg is a medication used to treat various conditions, including certain types of cancer, autoimmune diseases such as rheumatoid arthritis, and psoriasis. It is an antimetabolite and folate antagonist that works by inhibiting the activity of the enzyme dihydrofolate reductase, which is essential for the synthesis of DNA and cell division. This action slows the growth of cancer cells and reduces inflammation in autoimmune conditions.

The 2.5 mg dosage is typically taken in cycles, often weekly, depending on the condition being treated. For conditions like rheumatoid arthritis, it is commonly taken once a week, while for cancer treatments, it may be part of a more complex regimen. Common side effects include nausea, mouth sores, fatigue, and liver enzyme changes. Regular monitoring, including blood tests, is essential to detect any adverse effects and ensure safe use of the medication.