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Methotrexate Tablets IP 5 mg is a medication used for treating various conditions, including certain types of cancer (such as leukemia and lymphoma), autoimmune diseases (like rheumatoid arthritis, psoriasis, and Crohn’s disease), and ectopic pregnancy. Methotrexate is an antimetabolite and folate antagonist that works by inhibiting the enzyme dihydrofolate reductase, which is necessary for DNA synthesis and cell division. This action helps to slow the growth of cancer cells and reduce inflammation in autoimmune conditions.

The 5 mg dosage is typically taken weekly for conditions like rheumatoid arthritis, psoriasis, or Crohn’s disease, while for cancer treatment, it may be part of a larger chemotherapy regimen. Common side effects may include nausea, mouth sores, fatigue, liver toxicity, and low blood cell counts. Regular monitoring through blood tests and liver function tests is essential to ensure safe use of the medication.